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Now, let’s talk about the treatment approaches for **HER2-negative** breast cancer. Since HER2-negative breast cancer isn’t driven by the HER2 protein, targeted therapies aren’t effective. Treatment will instead focus on other approaches, such as **surgery**, **radiation therapy**, **chemotherapy**, and sometimes, **hormonal therapy**. Surgery is often the first step to remove the tumor. The type of surgery (lumpectomy or mastectomy) depends on various factors like tumor size and location. Radiation therapy is often used after surgery to kill any remaining cancer cells in the breast or nearby lymph nodes. Chemotherapy uses drugs to kill cancer cells throughout the body. It may be given before surgery to shrink the tumor or after surgery to eliminate any cancer cells that may have spread. If the cancer is hormone-receptor-positive (meaning the cancer cells have receptors that respond to hormones like estrogen and progesterone), hormonal therapy may be used. This involves taking drugs that block or lower hormone levels to starve the cancer cells. The treatment plan is highly individualized and determined by many factors. This includes the stage of the cancer and the cancer’s hormone receptor status.
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