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The IMpassion130 trial was a landmark study that demonstrated the efficacy of atezolizumab in combination with nab-paclitaxel (a form of the chemotherapy drug paclitaxel) for patients with metastatic TNBC whose tumors expressed PD-L1. The results showed a significant improvement in progression-free survival (the time until the cancer starts to grow again) for patients treated with the combination therapy compared to those treated with nab-paclitaxel alone. Based on these findings, atezolizumab was approved by the FDA for this indication, marking a major milestone in the treatment of TNBC. However, it's important to note that the benefit of atezolizumab was primarily observed in patients whose tumors had high levels of PD-L1 expression, highlighting the importance of biomarker testing to identify patients who are most likely to respond to this treatment.
