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In conclusion, the story of **PSA Flight 1771** is a tragic reminder of the fragility of life and the importance of aviation safety. The events of that day, the investigation that followed, and the lasting impact on the aviation industry serve as a stark warning. The crash of **PSA Flight 1771** serves as a stark reminder of the importance of aviation safety. By remembering the victims, understanding the causes, and implementing effective safety measures, we can work towards a safer future for air travel. Thanks for hanging out, and always fly safe, guys!
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Okay, so we know GLP-1 is important, but what about *endogenous* GLP-1? Endogenous just means it's produced inside our bodies, as opposed to something we take as medication. The big question is, how effective is our own GLP-1 at stimulating insulin secretion in people with type 2 diabetes? Sadly, it's not as effective as we'd like. In individuals with type 2 diabetes, the secretion of GLP-1 in response to eating is often reduced. Even when it is released, its effect on insulin secretion can be blunted. This is partly because the pancreas cells that produce insulin (beta cells) become less responsive to GLP-1 over time. Think of it like your favorite song – after hearing it a million times, it just doesn't have the same impact, right? Similarly, in type 2 diabetes, the beta cells become less sensitive to the signals from GLP-1.
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* **@jonmachota**: The Athletic's Dallas Cowboys beat writer. Offers comprehensive coverage of the team, including articles and analysis.
